Structure-based design of sulfonamide-substituted non-peptidic HIV protease inhibitors

J Med Chem. 1995 Dec 22;38(26):4968-71. doi: 10.1021/jm00026a002.
No abstract available

MeSH terms

  • Animals
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacokinetics
  • Antiviral Agents / pharmacology
  • Dogs
  • Drug Design*
  • HIV / drug effects*
  • HIV Protease / metabolism
  • HIV Protease Inhibitors / chemistry*
  • HIV Protease Inhibitors / pharmacokinetics
  • HIV Protease Inhibitors / pharmacology*
  • HIV-1 / drug effects
  • HIV-1 / enzymology
  • HIV-2 / drug effects
  • HIV-2 / enzymology
  • Hydrogen Bonding
  • Models, Molecular
  • Monte Carlo Method
  • Pyrones / chemistry*
  • Pyrones / metabolism
  • Pyrones / pharmacokinetics
  • Pyrones / pharmacology*
  • Rats
  • Sulfonamides / chemistry*
  • Sulfonamides / metabolism
  • Sulfonamides / pharmacokinetics
  • Sulfonamides / pharmacology*

Substances

  • Antiviral Agents
  • HIV Protease Inhibitors
  • Pyrones
  • Sulfonamides
  • U 103017
  • HIV Protease